10 studies comparing anteromedial and transtibial drilling techniques for anterior cruciate ligament (ACL) reconstruction were included for analysis. All studies were qualitatively compared while only 6 studies were used for meta-analysis. The purpose of the study was to determine if the anteromedial technique resulted in improved clinical outcomes following ACL reconstruction when compared to the transtibial technique. Pooled analysis found better results in anteromedial drilling compared to transtibial drilling for post-operative Lachman, pivot-shift, and IKDC test scores, but no difference between groups was seen for Lysholm score. Qualitative analysis found the anteromedial technique to be greater or equivalent to the transtibial technique across all measures, except for 1 study stating that the AM technique may result in a greater risk of revision ACL surgery. Results should be interpreted with caution as studies of lower methodological quality were included.