Impact of Perioperative Systemic Steroid Administration on Primary Total Hip Arthroplasty .
Impact of peri-operative systemic steroids administration on primary total hip arthroplasty. A meta-analysis of prospective randomized trials
Eight randomized controlled trials including 675 patients with hip osteoarthritis were included in this systematic review and meta-analysis comparing perioperative systemic steroid administration versus placebo in elective total hip arthroplasty. Pooled outcomes of interest included length of stay, pain, opioid consumption, postoperative nausea and vomiting (PONV), and inflammatory response. The results showed significant benefits in terms of reduced length of stay, pain, opioid consumption, PONV, and inflammatory response with perioperative steroids. High-dose steroids (>20 mg) specifically reduced inflammatory markers like C-reactive protein and IL-6 at 24 and 48 hours. These findings suggest that perioperative systemic steroids can enhance recovery without increasing postoperative complications in total hip arthroplasty.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics