Sixty patients who underwent a unilateral, primary computer-assisted surgery total knee arthroplasty (TKA) were randomized to receive continuous passive motion (CPM) physiotherapy combined with cryotherapy or routine post-operative nursing procedure (no CPM or cryotherapy). The primary outcome of interest was pain on a numeric rating scale (NRS). The secondary outcomes of interest included the short-form McGill Pain Questionnaire (SF-MPQ) and subscores, range of motion (ROM), and status of joint swelling, measured at post-operative days (PODs) 1 and 4. The results revealed that the NRS pain scores were not statistically significantly different between the 2 groups (p=0.168). Similarly, the all 15 SF-MPQ sub-scores were not statistically significantly different between the control and intervention groups. Joint swelling was not statistically significantly different between groups (p=0.157). However, ROM was statistically significantly higher in the intervention compared to the control at POD4 (p=0.007).