IL-1 receptor antagonist improves knee function of acute knee injuries with an ACL tear .
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Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254).
Osteoarthritis Cartilage. 2012 Apr;20(4):271-8. Epub 2012 Jan 1011 patients with acute knee injuries, occurring within 30 days of evaluation and presenting with an ACL tear, were randomized to receive an intraarticular injection with an IL-1 receptor antagonist (IL-1Ra) or saline. Authors hypothesized that injection with IL-1Ra would improve KOOS pain and functional scores over a 2 week follow-up period prior to operative reconstruction. Results indicated that the IL-1Ra group demonstrated a significant improvement from baseline measures over the 2 week period; whereas, the placebo group did not have a similar improvement.
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