IA injection of US-approved viscosupplements safe and effective at 26 weeks in knee OA .
Safety and efficacy of US-approved viscosupplements for knee osteoarthritis: a systematic review and meta-analysis of randomized, saline-controlled trials
J Pain Res. 2015 May 7;8:217-2829 randomized controlled trials, with a total of 4,886 patients were included in this meta-analysis to analyze the safety and efficacy of US-approved viscosupplements in symptomatic knee osteoarthritis (OA) treatment. Results indicated that intra-articular injection of viscosupplements may be safe and effective through 26 weeks, as they resulted in large treatment effects for knee pain and function compared to pre-injection values, and significant treatment effects compared to control saline injection groups. No significant differences were found in safety outcomes or risk adverse events.
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