IA injection of morphine + bupivacaine vs. morphine alone for analgesia after arthroscopy .
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2016;4(2):31 PLoS One. 2015 Oct 16;10(10):e014051213 randomized controlled trials were included in this systematic review and meta-analysis to determine the safety and efficacy of a single intra-articular injection of morphine + bupivacaine compared to morphine alone in managing pain after knee arthroscopy. Pooled analysis found combined treatment to significantly lower pain in the immediate postoperative period (0-2 hours) and significantly increase the time to first request for rescue analgesia compared to morphine alone. No significant differences in pain intensity from 2-48 hours or in the number of patients requiring rescue analgesia was observed between groups. Qualitative analysis found adverse events to be similar between treatment groups.
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Was the validity of all of the studies referred to in the text assessed with use of appropriate criteria (either in selecting the studies for inclusion or in analyzing the studies that were cited)?
Were the methods used to combine the findings of the relevant studies (to reach a conclusion) reported?
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Introduction
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Accessing Data
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Analysing Data
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Results
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Discussion
Detsky AS, Naylor CD, O'Rourke K, McGeer AJ, L'Abbé KA. J Clin Epidemiol. 1992;45:255-65
Der Fragilitätsindex ist ein Instrument, das bei der Interpretation signifikanter Ergebnisse hilft und ein Maß für die Stärke eines Ergebnisses liefert. Der Fragilitätsindex gibt die Anzahl der aufeinanderfolgenden Ereignisse an, die zu einem dichotomen Ergebnis hinzugefügt werden müssen, damit das Ergebnis nicht mehr signifikant ist. Eine kleine Zahl steht für ein schwächeres Ergebnis und eine große Zahl für ein stärkeres Ergebnis.
Warum wurde diese Studie jetzt benötigt?
Knee arthroscopy is a procedure often accompanied by moderate-to-severe postoperative pain, making pain management an important consideration for patient recovery and decreased length of hospital stay. Intra-articular (IA) injections of local anaesthetic and analgesics have gained popularity given their practical application. Two common treatments with different mechanisms of action include morphine and bupivacaine. While both have proven effective in IA injection, their onset and duration of action vary. A combination of these two drugs may provide an earlier onset and longer duration of analgesia. However, previous studies have shown conflicting evidence regarding the efficacy of combination treatment over morphine alone, indicating a need for the present systematic review and meta-analysis.
Was war die wichtigste Forschungsfrage?
How safe and efficacious is a single-dose intra-articular injection of morphine plus bupivacaine in comparison to morphine alone in managing pain up to 48 hours after knee arthroscopy?
- During the immediate post-operative period (0-2h), the combined treatment group showed a significantly lower postoperative pain intensity compared with the morphine group (9 studies; 305 patients; WMD: -1.16 [95% CI -2.01, -0.31]; p=0.007; I2=82%)
- During the early post-operative (2-6h) and late post-operative (6-48h) periods, no significant difference in pain intensity was observed between groups (Early: 8 studies; 237 patients; WMD: -0.36 [95% CI -1.13, 0.41]; p=0.35; I2=67% | Late: 8 studies; 257 patients; WMD: 0.32 [95% CI -0.32, 0.95]; p=0.33; I2=61%)
- Time to first analgesic request was significantly greater in the combined treatment group compared with the morphine group (4 studies; 216 patients; WMD: 2.05 [95% CI 0.19, 3.92]; p=0.03; I2=95%)
- No significant difference was observed between groups in the number of patients requiring supplementary analgesia (6 studies; 146 patients; RR: 0.78 [95% CI 0.57, 1.05]; p=0.10; I2=0%)
- Sensitivity analyses confirmed all quantitative results except for difference in time to first analgesic request, which became insignificant between groups when studies that used epinephrine in the intervention treatment were removed (WMD: 2.20 [95% CI 0.01, 4.40]; p=0.05; I2=97%)
- Adverse events were reported in 7 of 13 studies: 2 studies observed urinary retention, nausea and vomiting with no significant differences between groups, 4 studies found no adverse effects in either group
Was sollte ich mir besonders merken?
Following knee arthroscopy, a combined intra-articular injection of morphine and bupivacaine significantly lowered immediate (0-2 hours) postoperative pain intensity and increased time to first request for rescue analgesia compared to morphine alone. Sensitivity analysis removing studies which used epinephrine resulted in a nonsignificant between group difference in time to first analgesic request. No significant differences were observed between groups in terms of pain intensity during the early and late post-operative period (2-48 hours) or number of patients requiring rescue analgesia. Qualitative analysis found no significant difference in adverse events between groups.
Wie wird sich dies auf die Behandlung meiner Patienten auswirken?
Results suggest that for patients undergoing knee arthroscopy, administration of a single intra-articular injection of morphine plus bupivacaine provides better immediate pain relief and extended time until first analgesic request as compared to an injection of morphine alone, with no difference in adverse events. Further high-quality RCTs with homogeneous reporting methods and longer follow-up periods are required to effectively assess adverse events through pooled analysis.
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