Fifty-two patients who underwent total knee replacement were randomized to receive either a nurse-led hybrid teaching program (n=26) or routine care alone (n=26). The hybrid teaching program included routine care plus 16 weeks of home rehabilitation through an educational manual, video instructions, and monthly telephone follow-ups. The primary outcome of interest was knee function, while secondary outcomes included lower limb muscle strength and depression. Outcomes were assessed over 16 weeks post-surgery. Overall, the results revealed that the hybrid teaching program significantly improved quadriceps strength, hamstring strength, and knee function, with no significant difference in depression between groups. These findings suggest that a hybrid teaching program can enhance physical function after total knee replacement.