Intra-articular treatment of knee osteoarthritis. A comparative study between hyaluronic acid and 6-methyl prednisolone acetate

40 knee osteoarthritis (OA) patients were randomized to undergo treatment with intra-articular injections of either sodium hyaluronate (NaHA) or 6-methylprednisolone (6-MPH). The purpose of the study was to compare the two interventions in terms of pain, stiffness, function, and tolerability. Although significantly greater benefits were reported for pain outcomes in patients undergoing treatment with NaHA, stiffness and function remained comparable between the groups. The treatment was well tolerated by all patients.