Hyaluronate vs distention vs placebo for Knee OA: no difference in osteoarthritis .
Intra-articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial.
. 2008 ;():.
251 patients with symptomatic knee osteoarthritis, who did not respond to conservative or pharmaceutical treatment, were randomized to receive either hyaluronate, 20 mL saline (distention) or 2 mL saline placebo as an intra-articular injection. The purpose of this study was to compare changes in pain and function of the affected knee between the treatment groups. Results indicated that over a 26 week period there were no significant differences between the hyaluronic acid group and the placebo group, with the exception of extension ability and global assessments by the physician.
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