Eight randomized controlled trials including 434 patients with isolated meniscal tears treated via arthroscopic meniscectomy were included in this systematic review and meta-analysis comparing home-based rehabilitation (HBP) versus supervised inpatient and/or outpatient physical therapy (IOP). Pooled outcomes of interest included the Lysholm score, subjective IKDC score, knee flexion and extension, thigh girth, hop test performance, and return-to-work time. Short-term results showed that IOP was associated with slightly better Lysholm scores and vertical hop performance, while HBP showed better thigh girth outcomes. However, midterm results showed no significant differences in primary or secondary outcomes between groups. These findings suggest that HBP may be a clinically effective and cost-efficient alternative to supervised rehabilitation post-meniscectomy.