AMSSM scientific statement concerning viscosupplementation injections for knee osteoarthritis: importance for individual patient outcomes

This report has been verified by one or more authors of the original publication.

この研究はハイインパクトの可能性があります。 OEのAI駆動型ハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文が持つ可能性の高い影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することが可能になり、読者は将来の診療を形成する可能性が最も高い論文に集中することができます。

11 randomized controlled trials were included in this traditional meta-analysis and network meta-analysis comparing the efficacy of intra-articular injections of hyaluronic acid (IA-HA), corticosteroids (IA-CS), and placebo (IA-P) in the treatment of patients with mild-moderate knee osteoarthritis. The primary end point was the treatment response rate according to the Outcome Measures in Rheumatoid Arthritis Clinical Trials-Osteoarthritis Research Society International (OMERACT-OARSI) criteria, and the secondary end points included standard mean differences in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, and stiffness scores. All data came between 8 and 26 weeks post-injection time points. Network meta-analysis demonstrated significance in favour of IA-HA over both IA-CS and IA-P regarding OMERACT-OARSI response rate and WOMAC function scores, and, additionally, significance in favour of IA-HA over IA-P in WOMAC pain scores. No significant difference between treatments was observed in network meta-analysis of WOMAC stiffness scores. Based on the results of the analysis, the American Medical Society for Sports Medicine put forth the recommendation of using IA-HA for the treatment of mild-moderate knee osteoarthritis in patients over the age of 60 years.