High intensity exercise for 3 months reduces disease activity in axial spondyloarthritis (axSpA): a multicentre randomised trial of 100 patients.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

One hundred patients with axial spondyloarthritis were randomized to receive 12-week high intensity exercise program, or standard care with maintenance of usual physical activity levels. The primary outcomes of interest included disease activity measured by the Ankylosing Spondylitis Disease Activity Score (ASDAS), C-reactive protein (CRP) levels, and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) total score and sub-scores (neck/back/hip pain, peripheral pain, morning stiffness, morning stiffness duration, fatigue, and tenderness). Additional outcomes of interest included physical function via the Bath Ankylosing Spondylitis Functional Index (BASFI), spinal mobility via the Bath Ankylosing Spondylitis Metrology Index (BASMI), estimated peak VO2, maximum and resting heart rate, maximal effort, weight, BMI and waist circumference. All outcomes were measured at 3 months follow-up. The results demonstrated that all primary outcomes were statistically significantly in favour of the high intensity exercise intervention (p<0.05 for all), with the exception of BASDAI tenderness sub-score (p=0.059). For secondary outcomes, BASFI scores (p<0.001), BASMI scores (p=0.016), estimated peak VO2 (p<0.001), and waist circumference (p=0.031) were all statistically significantly in favour of the high intensity exercise group.