Glucosamine + chondroitin reduced joint space narrowing at 2 years vs. placebo in knee OA .
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Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens
Ann Rheum Dis. 2015 May;74(5):851-8.605 patients with osteoarthritis (OA) of the knee and resultant chronic knee pain were recruited to the study. Participants were randomized to consume glucosamine, chondroitin, a combination of both, or a placebo once daily for 2 years. The purpose of the study was to assess the effect on the supplements on joint space narrowing (JSN), pain, and function. The trial found that groups were comparable in all outcomes, with the exception of the combination of glucosamine and chondroitin displaying significantly reduced JSN in comparison to the placebo group at 2 years.
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