ARTHROPLASTY
Glucagon-like peptide-1 receptor agonists are associated with improved 90-day outcomes after total hip and knee arthroplasty : a systematic review and meta-analysis.
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OrthoEvidence Journal (OE Journal) - ACE Report
Epub Ahead of Print
Bone Joint J. 2026 07-Sep;():. 10.1302/0301-620X.108B8.BJJ-2025-1486.R2Study Summary
10 studies including 96 356 patients undergoing primary total hip arthroplasty (THA) or total knee arthroplasty (TKA), many with obesity or type 2 diabetes, were included in this systematic review and meta-analysis comparing patients receiving glucagon-like peptide-1 receptor agonists (GLP-1RAs) with those not receiving these medications. Pooled outcomes included 90-day surgical complications, medical complications, readmissions, revision rates, healthcare costs, and hospital length of stay. GLP-1RA use was associated with fewer short-term surgical and medical complications and lower readmission rates, with stronger associations observed following THA. Overall, preoperative GLP-1RA treatment was associated with improved early arthroplasty outcomes, although the observational evidence did not establish a causal benefit.
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