Gabapentin improves in-hospital rehabilitation but not post-discharge outcomes after TKA .
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Perioperative gabapentin reduces 24 h opioid consumption and improves in-hospital rehabilitation but not post-discharge outcomes after total knee arthroplasty with peripheral nerve block
Br J Anaesth. 2014 Nov;113(5):855-64.179 patients undergoing total knee arthroplasty (TKA) were randomized to receive a four day perioperative regimen of either gabapentin or placebo as an adjunct to celecoxib. The primary intent of this trial was to determine whether gabapentin improves in-hospital rehabilitation and physical function 4 days, 6 weeks, and 3 months after surgery. No significant differences in favour of gabapentin were observed with respect to pain and physical function at any follow-up time point. However, gabapentin decreased morphine consumption in the first 24 hours after surgery, reduced the incidence of nausea, pruritus and dizziness, and increased in-hospital knee range of motion compared to placebo.
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