Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin

ملخص الدراسة

12 adult migraine patients underwent an exploratory, proof-of-concept, double-blind, placebo-controlled, cross-over study to test the effects of psilocybin on migraines. Patients received a placebo and psilocybin dose and outcome measures were taken two weeks after administration. The primary outcome measures were the change in migraine frequencies, change in weekly migraine attacks, light sensitivity, sound sensitivity, nausea/vomiting and attack-related functional impairment. There was a significant reduction in weekly migraine days after psilocybin treatment compared to the placebo. These changes in migraine frequency were not correlated with the intensity of acute psychotropic effects. Psilocybin was well-tolerated, with no serious adverse events.