Impact of Exercise Therapy on Molecular Biomarkers Related to Cartilage and Inflammation in Individuals at Risk of, or With Established, Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

The benefits of exercise are wide-ranging and well-documented. In the context of knee osteoarthritis, however, there is debate about the benefits of exercise therapy. While exercise therapy is sure to be beneficial to the patient's overall health and metabolic profile, it is less clear whether exercise - especially weight-bearing exercise - improves or worsens disease in patients with or at risk of osteoarthritis (OA). In this meta-analysis of randomized controlled trials, the authors assess whether exercise therapy, compared to non-exercise controls, had an impact on the biochemical markers of inflammation in patients with or at risk of knee OA. They found that among 9 biomarkers including C-reactive protein, Tumour Necrosis Factor (TNF-alpha), and interleukin-6 (IL-6), none of the biomarkers were significantly raised or lower due to exercise therapy. Overall, there is no evidence that exercise significantly increases or decreases inflammation, at least based on surrogate outcomes.