Ewing sarcoma: Similar survival rates with intensified dose regimen of VDC/IE .
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Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children's Oncology Group Study
J Clin Oncol. 2009 May 20;27(15):2536-41. doi: 10.1200/JCO.2008.19.1478. Epub 2009 Apr 6478 patients under the age of 30, diagnosed with non-metastatic ESFT (or the Ewing sarcoma family of tumours), were randomized to either a standard or intensified dose regimen of vincristine, doxorubicin, and cyclophosphamide (VDC) along with ifosfamide and etoposide (IE) to assess the 5-year event-free and overall survival rates between groups. Results indicated that there was no significant difference between groups in the 5-year event-free and overall survival rates or the incidence of secondary leukemia. However, the frequency of solid secondary tumours was higher in the intensified group, and half of these cases had not been treated with radiation.
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