The Use of Erythromycin and Colistin Cement in Total Knee Arthroplasty Does Not Reduce the Incidence of Infection: A Randomized Study in 2,893 Knees With a 9-year Average Follow-Up.

研究概要

Two thousand eight hundred ninety-three knees from patients undergoing primary total knee arthroplasty were randomized to receive plain bone cement (n=1,452) or erythromycin and colistin-loaded bone cement (n=1,441). The primary outcome of interest was the rate of deep prosthetic joint infection. Secondary outcomes included rates of aseptic loosening and antibiotic resistance in infecting organisms. Outcomes were assessed over an average follow-up of 8.7 years. Overall, the results revealed no significant differences in the rate of infections or aseptic loosening between the groups. The findings suggest that using erythromycin and colistin-loaded bone cement does not provide additional benefits in reducing infections or aseptic loosening in TKA.