Study Summary

Eighty-four patients with bilateral moderate carpal tunnel syndrome (CTS) (168 wrists) were randomized to receive ultrasound-guided corticosteroid injections or landmark-guided injections. The primary outcomes of interest were symptom severity and functional status measured by the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ-SSS and BCTQ-FSS). Secondary outcomes included grip strength, median nerve cross-sectional area, flattening ratio, and electrophysiological parameters. Outcomes were assessed at baseline, 1 month, and 6 months. Overall, the results of the study revealed that both groups showed significant improvements in all clinical and electrophysiological outcomes, with no significant differences between groups. These findings suggest that both ultrasound-guided and landmark-guided injections are equally effective for moderate CTS, although ultrasound guidance may reduce minor complications.