Efficacy of Platelet-Rich Plasma Versus Placebo for the Treatment of Greater Trochanteric Pain Syndrome: A Double-Blinded Randomized Controlled Trial.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2025;13(9):6 J Bone Joint Surg Am . 2025 Mar 5;107(5):444-451.What this means for my practice?
Clinicians should remember that a single ultrasound-guided LR-PRP injection does not improve functional or pain outcomes compared to placebo in patients with refractory GTPS. These findings suggest no added benefit of PRP over placebo, and its routine use in this context is not supported. Limitations include lack of analysis of growth factor concentration in the PRP and the absence of imaging to assess structural healing.
Study Summary
Seventy-nine patients with greater trochanteric pain syndrome unresponsive to conservative treatment were randomized to receive a single ultrasound-guided injection of leukocyte-rich platelet-rich plasma (n=39) or saline placebo (n=40). The primary outcome of interest was the iHOT-12 score. Secondary outcomes included VAS for pain, EQ-5D index, EQ-5D VAS, and mHHS scores. Outcomes were assessed at 3, 6, and 12 months. Overall, the results of the study revealed no significant differences in any outcome measures between the PRP and placebo groups at any follow-up point. This suggests that LR-PRP does not provide added clinical benefit over placebo in treating refractory GTPS.
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