Efficacy of Duloxetine vs Placebo for Postspine Surgery Pain in Adult Patients .
Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta-Analysis.
Brain Behav. 2025 Jan;15(1):e70217.Seven studies including 273 patients undergoing various spine surgeries were included in this systematic review and meta-analysis comparing perioperative duloxetine to placebo. Pooled outcomes of interest included postoperative pain at 2, 24, and 48 hours, total analgesic consumption within 24 hours, time to first rescue analgesia, and adverse events such as nausea, vomiting, somnolence, and itching. Duloxetine significantly reduced pain intensity at 24 hours, decreased analgesic consumption, and prolonged time to first analgesic request. No significant differences were observed in adverse effects. These findings suggest duloxetine may be an effective adjunct for acute postoperative pain after spine surgery, with a favorable safety profile.
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