Efficacy of Diosmin in Reducing Lower-Extremity Swelling and Pain After Total Knee Arthroplasty: A Randomized, Controlled Multicenter Trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

Three hundred thirty patients undergoing primary unilateral total knee arthroplasty for osteoarthritis were randomized to receive diosmin (n=167) or no diosmin (n=163). The diosmin group received 0.9 g twice daily for 14 days postoperatively, while the control group received no treatment or placebo. The primary outcome of interest was lower-extremity swelling measured at 24, 48, and 72 hours, and 14 days postoperatively. Secondary outcomes included pain during motion, pain at rest, Hospital for Special Surgery (HSS) scores, range of motion, levels of inflammatory biomarkers (C-reactive protein and interleukin-6), and the incidence of complications. Outcomes were assessed up to 14 days postoperatively. Overall, the results of the study revealed that diosmin significantly reduced lower-extremity swelling and pain during motion compared to the control group. The study suggests that diosmin may be beneficial in reducing postoperative swelling and pain after TKA, but further research is needed to confirm its efficacy and safety.