Efficacy of Cryoneurolysis on Chronic Pain in Patients with Knee Osteoarthritis: A Double-blinded Randomized Controlled Sham Trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

Eighty-seven patients with chronic knee osteoarthritis were randomized to receive either cryoneurolysis (n=44) or a sham procedure (n=43). Both groups subsequently participated in an 8-week structured exercise program (GLA:D). The primary outcome was the difference in average pain over the previous 24 hours at 14 days post-intervention. Secondary outcomes included worst and least pain, pain during activity and rest, functional tests (e.g., chair stand, 40-m walk), isometric strength, and patient-reported outcomes (e.g., KOOS, EQ-5D, anxiety). Outcomes were assessed at baseline, 14 days, post-GLA:D, and at 6 and 12 months. Overall, the results revealed no significant difference in pain between groups at 14 days (primary endpoint), although minor improvements in least pain and walk time were noted in the cryoneurolysis group at 6 months. These effects were not sustained at 12 months. This suggests that the tested cryoneurolysis protocol does not confer a meaningful clinical benefit over sham in this population.