One hundred and fifty-six patients with unilateral, acute, uncomplicated lateral ankle sprains were randomized to receive 7 days of etofenamate plaster use (n=78) or a placebo plaster (n=78) for pain relief. The primary outcome of interest was the change from baseline in Visual Analog Scale (VAS) pain on movement scores at 72 hours. Additionally, pain scores during rest and movement, time to response, and adverse events were recorded over the 7 day treatment period. Results revealed significantly greater pain relief, both at rest and during movement, in the etofenamate group compared to placebo throughout the 7 day treatment period. In the etofenamate group, the time to a meaningful and optimal response was shorter than placebo. 3 adverse events were observed in the placebo group vs. 2 adverse events in the etofenamate group, all of mild/moderate intensity.