Early Intra-articular Hyaluronic Acid Injection After Anterior Cruciate Ligament Reconstruction Provides Short-Term Pain Relief and Improves Early Postoperative Function With No Clinical Benefits at 6 and 12 Months: A Randomized Controlled Trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

90 patients undergoing primary arthroscopic anterior cruciate ligament (ACL) reconstruction were randomized to receive early hyaluronic acid (HA) injection on postoperative day 2, delayed hyaluronic acid injection at 2 months, or placebo saline injections at both time points. One patient in the delayed hyaluronic acid group was excluded due to postoperative donor-site infection, and two patients were lost to follow-up, resulting in 87 patients completing the study. The primary outcome of interest was the proportion of patients achieving a Lysholm score greater than 83, indicating good-to-excellent knee function. Secondary outcomes included pain intensity (VAS), knee range of motion, International Knee Documentation Committee (IKDC) score, Tegner activity score, health-related quality of life (EQ-5D-5L and EQ-VAS), and inflammatory markers. Outcomes were assessed at baseline, monthly up to 6 months, and at 12 months postoperatively. Overall, the results of the study revealed that early hyaluronic acid injection led to superior pain relief, faster functional recovery, and improved quality of life during the first 1–2 months after surgery. However, these benefits were not sustained at 6 or 12 months.