Effectiveness of Pre-Emptive Analgesia on Post-Operative Pain After First-Time Lumbar Spine Surgery .
Is preemptive analgesia a good choice for postoperative pain relief in lumbar spine surgeries?: A meta-analysis of randomized controlled trials
Medicine (Baltimore). 2021 Apr 2; 100(13): e25319.Seven studies containing a total of 509 patients undergoing a first-time lumbar spine surgery were included in this meta-analysis comparing pre-emptive analgesia (n=255) and placebo (n=254) for post-operative pain relief. Pooled outcomes of interest included pain scores, opioid consumption in morphine equivalents, length of stay, and complications. Quantitative analysis results revealed significantly lower pooled pain scores at 24 hours (p=0.002), lower pooled opioid consumption at 24 and 48 hours (p=0.05; p=0.0006, respectively), and shorter pooled length of stay (p=0.04) in the pre-emptive analgesia group compared to the control group. No significant differences in pooled incidence of nausea and vomiting (p=0.63) or urinary retention (p=0.86) were observed between the two groups.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
