Effectiveness and safety of rivaroxaban or low-molecular-weight heparin in non-major orthopedic surgery: a meta-analysis of randomized controlled trials.

研究概要

Five randomized controlled trials, including 5101 patients undergoing non-major orthopedic surgery, were analyzed to compare rivaroxaban with LMWH for thromboprophylaxis. Pooled outcomes of interest included venous thromboembolism (VTE), deep vein thrombosis (DVT), pulmonary embolism (PE), overall bleeding events, and major bleeding events. The results showed no significant difference between rivaroxaban and LMWH in preventing VTE or in the incidence of bleeding events. These findings suggest that both treatments have comparable efficacy and safety profiles for patients undergoing non-major orthopedic surgery.