ACE Report Cover
Effect of Teriparatide on the healing of femoral neck fractures remains uncertain
Language
Download
Cite
+ Favorites
Language
Download
Cite
+ Favorites
AceReport Image
TRAUMA
Effect of Teriparatide on the healing of femoral neck fractures remains uncertain .
Verified
This report has been verified by one or more authors of the original publication.

Does Teriparatide Improve Femoral Neck Fracture Healing: Results From A Randomized Placebo-controlled Trial

Clin Orthop Relat Res. 2016 May;474(5):1234-44

161 men and postmenopausal women undergoing treatment with internal fixation for a unilateral femoral neck fracture resulting from a low-trauma event were randomized in two concurrent trials to receive either Teriparatide or a placebo once daily for 6 months. This study was conducted to determine if the benefits observed in revision rates, radiographic healing, and clinical outcomes with the use of Teriparatide in preclinical and preliminary clinical data were replicable in a hip fracture patients. Due to the slow accrual of patients enrollment was stopped early in these trials well before the planed sample size was reached. The analysis of the patients who were enrolled indicated that the use of Teriparatide did not provide a reduction in the risk of revision surgery, improve signs of radiographic healing, or decrease pain when compared to a placebo. These results should be interpreted with caution as the small sample size limited the power of this study to detect potential differences. Larger well designed randomized controlled trials are needed to further investigate the effects of Teriparatide in bone healing.

Unlock the Full ACE Report

You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now

Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics

Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics

Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions

Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics

Or upgrade today and gain access to all OrthoEvidence
content for as little as $1.99 per week.
0 of 4 monthly FREE articles unlocked
You've reached your limit of 4 free articles views this month

Access to OrthoEvidence for as little as $1.99 per week.

Stay connected with latest evidence. Cancel at any time.
  • Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
  • Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
  • Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Upgrade
Welcome Back!
Forgot Password?
Start your FREE trial today!

Account will be affiliated with


OR
Forgot Password?

OR
Please check your email

If an account exists with the provided email address, a password reset email will be sent to you. If you don't see an email, please check your spam or junk folder.

For further assistance, contact our support team.

Translate ACE Report

OrthoEvidence utilizes a third-party translation service to make content accessible in multiple languages. Please note that while every effort is made to ensure accuracy, translations may not always be perfect.

Cite this ACE Report

OrthoEvidence. Effect of Teriparatide on the healing of femoral neck fractures remains uncertain . ACE Report. 2016;5(6):63. Available from: https://myorthoevidence.com/AceReport/Show/effect-of-teriparatide-on-the-healing-of-femoral-neck-fractures-remains-uncertain

Copy Citation
Please login to enable this feature

To access this feature, you must be logged into an active OrthoEvidence account. Please log in or create a FREE trial account.

Premium Member Feature

To access this feature, you must be logged into a premium OrthoEvidence account.

Share this ACE Report