Randomized, double-blind, placebo-controlled study to evaluate the effect of treatment with an SPMs-enriched oil on chronic pain and inflammation, functionality, and quality of life in patients with symptomatic knee osteoarthritis: GAUDI study.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

51 patients with symptomatic knee osteoarthritis were randomized to receive 12 weeks of specialized pro-resolving mediators (SPM) supplementation via soft gels (n=23) or a placebo with olive oil (n=28). The primary outcome of interest was the change in Visual Analog Scale (VAS) pain score from baseline at 12 weeks follow-up. Secondary outcomes included joint function according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), constant/intermittent/total pain scores on the OMERACT-OARSI score, and health-related quality of life on the EuroQoL-5 questionnaire. Follow-up was continued up to 24 weeks (12 weeks after completion of treatment). VAS pain scores at 8 and 12 weeks were significantly lower in the SPM group; the improvement in intermittent pain scores was significantly greater in the SPM group, and total pain score improvement trended in favor of the SPM group. More patients in the SPM group showed significant improvement in EQ-VAS scores in the usual activities dimension compared to the placebo group. The results of this study suggest SPM supplementation could provide significant improvement in pain and quality of life for patients with knee osteoarthritis, however, it has little residual effect after cessation of treatment.