Effect Of Pain Reprocessing Therapy vs Placebo And Usual Care for Patients With Chronic Back Pain .
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Effect of Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: A Randomized Clinical Trial.
JAMA Psychiatry . 2022 Jan 1;79(1):13-23.One hundred fifty-one adults with chronic primary back pain were randomized to receive pain reprocessing therapy (n=50), open-label placebo (n=51), or usual care (n=50). The primary outcome was average back pain intensity over the past week at posttreatment. Secondary outcomes included pain-related disability, depression, anxiety, anger, sleep quality, and positive/negative affect. Outcomes were assessed at 1 month post-treatment and up to 12 months for follow-up. Overall, the results revealed that patients in the PRT group had significantly greater reductions in pain intensity compared to both control groups, with 66% reporting being pain-free or nearly pain-free after treatment. These improvements were largely sustained at 1-year follow-up. The findings suggest that PRT can provide substantial and durable pain relief by targeting pain-related beliefs.
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