Local infiltration analgesia following total knee arthroplasty: effect on post-operative pain and opioid consumption-a meta-analysis

7 randomized trials comparing the use of local infiltration analgesia (LIA) versus placebo in total knee arthroplasty were included in this meta-analysis. The purpose of this study was to evaluate pain scores and opioid consumption over the first 2 days postoperatively. Pooled analyses demonstrated significantly lower pain and opioid consumption among LIA-treated groups compared to placebo-treated groups at 24 hours postoperatively, but not at 48 hours. Heterogeneity in LIA protocols limit the results of the current analysis.