Effect of intra-operative Magnesium sulphate on the occurrence of post-operative delirium and insomnia in patients undergoing lumbar fixation: a randomized controlled trial.
OrthoEvidence Journal (OE Journal) - ACE Report
OE Journal. 2025;13(1):47 BMC Anesthesiol . 2024 Aug 13;24(1):289.What this means for my practice?
Magnesium sulfate effectively reduces postoperative insomnia and pain in lumbar fixation patients, suggesting its utility as an adjuvant to anesthesia. While its effect on delirium is inconclusive, its role in improving sleep and pain management highlights its potential to enhance postoperative recovery. Limitations include the small sample size and absence of direct magnesium level measurements, warranting further research.
Study Summary
Eighty patients undergoing lumbar fixation were randomized to receive either conventional general anesthesia with intraoperative magnesium sulfate (n=40) or conventional general anesthesia only (n=40). The primary outcome was the occurrence of postoperative delirium and insomnia, assessed using the Memorial Delirium Assessment Scale (MDAS) and Insomnia Severity Index (ISI), respectively. Secondary outcomes included pain scores (Visual Analog Scale, VAS) and predictors of these outcomes. Assessments were performed preoperatively and postoperatively up to two weeks. Overall, the study revealed that magnesium sulfate significantly reduced postoperative insomnia and pain but did not show a significant effect on delirium after adjustment. These findings suggest magnesium sulfate can mitigate insomnia and pain, potentially improving postoperative recovery.
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