Early Denosumab vs. Ibandronate in Intertrochanteric Fracture Healing: A Randomized Comparison .
Does early administration of denosumab delay bone healing after intertrochanteric femoral fractures?
J Orthop Sci. 2025 Jan;30(1):136-141.Sixty-six patients with intertrochanteric femoral fragility fractures were randomized to receive either denosumab (DSM) (n=33) or ibandronate (IBN) (n=33) within one week postoperatively. The primary outcome was radiological fracture healing at three months, assessed via plain radiographs and computed tomography (CT). Secondary outcomes included clinical healing, pain on loading, and walking ability. Outcomes were assessed up to six months postoperatively. Overall, the study found no significant differences in fracture healing rates between the two groups on radiographs or CT. Similarly, clinical healing rates were comparable at three and six months. The findings suggest that early administration of denosumab does not delay fracture healing compared to ibandronate.
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