Early bisphosphonate use after surgery does not appear to delay fracture healing .
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original publication.
Timing of the initiation of bisphosphonates after surgery for fracture healing: a systematic review and meta-analysis of randomized controlled trials
Osteoporos Int. 2015 Feb;26(2):431-41.10 studies with a total of 2888 patients in total were included in this meta-analysis and systemic review examining the use of bisphosphonates (BPs) in patients following a surgical procedure to treat a fracture. The purpose of the study was to determine whether early use of bisphosphonates (within 3 months of surgery) would have a negative impact on fracture healing time or not. The results indicated that patients receiving bisphosphonate therapy had similar radiological fracture healing times when compared to patients in the control group. Furthermore, rates of delay or nonunion of fracture healing were similar between early and delayed BP therapy groups.
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