Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functional Scores, Pain, and Psychological Distress After Arthroscopic Rotator Cuff Repair in Patients With Anxiety or Depression: Prospective Randomized Controlled Trial.

この研究はインパクトが大きい可能性があると判断されました。 OEのAIによるハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文の影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することができ、読者は将来の診療を形成する可能性が最も高い論文に焦点を当てることができます。

研究概要

63 patients undergoing arthroscopic rotator cuff repair for chronic rotator cuff tears were randomized into two treatment groups; psychological distress treated with duloxetine and psychological distress without duloxetine. The primary outcome of interest was active forward flexion at 3 months postoperatively. Secondary outcomes of interest included external rotation, internal rotation, American Shoulder and Elbow Surgeons (ASES) score, Simple Shoulder Test (SST) score, pain Visual Analogue Scale (VAS), Hospital Anxiety and Depression Scale (HADS) anxiety and depression scores, analgesic consumption, retear rate, satisfaction, and duloxetine-related adverse events. Outcomes were assessed through 3 months, 6 months, one year, and final follow-up, with pain and analgesic use also assessed in the immediate postoperative period. Overall, the results of the study revealed that duloxetine-treated patients with psychological distress had better early range of motion, functional scores, pain scores, anxiety scores, and lower opioid consumption than distressed patients who did not receive duloxetine. These findings suggest that duloxetine may help normalize early recovery after rotator cuff repair in patients with anxiety and/or depressive distress.