Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ opioid agonist Salvinorin A in humans

Questo studio è stato identificato come potenzialmente ad alto impatto. La metrica High Impact di OE, guidata dall'AI, stima l'influenza che un articolo potrebbe avere integrando i segnali della rivista in cui è stato pubblicato e il contenuto scientifico dell'articolo stesso. Sviluppato utilizzando un'elaborazione del linguaggio naturale all'avanguardia, il modello High Impact di OE prevede in modo più accurato la futura performance citazionale di uno studio rispetto al solo fattore di impatto della rivista. Ciò consente di riconoscere prima le ricerche clinicamente significative e aiuta i lettori a concentrarsi sugli articoli che hanno maggiori probabilità di influenzare la pratica futura.

Riassunto dello studio

Ten participants were included in this double-blind, randomized, crossover study examining the effects of salvinorin A (SA). Participants were administered 0 mg, 8 mg and 12mg of inhaled SA in a counterbalanced way over three sessions that were held consecutively over three days. Subjective and behavioural effects were measured using using a self-reported visual analogue scale (VAS), the Positive and Negative Syndrome Scale (PANSS), the Psychotomimetic States Inventory (PSI), the Clinician Administered Dissociative Symptoms Scale (CADSS), and the Hallucinogen Rating Scale (HRS). Cognitive effects were assessed using using a simple cognitive battery comprised of elements of the WAIS-R. Psychophysiological effects were measured with resting state EEG, blood pressure and heart rate. Plasma cortisol and prolactin levels were also assayed at various time points, as well as SA and salvinorin B levels using a modified liquid-chromatographic-atmospheric pressure chemical ionization-tandem mass spectrometric method. Results reveal that SA produced a wide range of transient, non dose-related effects including dissociative and somaesthetic effects, increased plasma cortisol and prolactin, and reduced resting EEG spectral power, especially for the beta and theta frequencies. SA levels in the blood rapidly increased following its administration. SA did not produce euphoria, cognitive deficits or changes in vital signs.