Does Melatonin Improve Subjective Sleep Quality After Total Knee Arthroplasty ?
The John N. Insall Award: Does Melatonin Improve Subjective Sleep Quality After Total Knee Arthroplasty? A Randomized, Placebo-Controlled Trial.
J Arthroplasty. 2024 01-Aug;():. 10.1016/j.arth.2024.01.018One hundred seventy-two patients undergoing total knee arthroplasty for osteoarthritis were randomized to receive either 5 mg melatonin (n=86) or 125 mg vitamin C placebo (n=86). The primary outcome was the Pittsburgh Sleep Quality Index (PSQI). Secondary outcomes included patient-reported measures of pain and physical function, opioid prescriptions, medication compliance, and adverse events. Outcomes were assessed at both 6 weeks and 90 days. Overall, the results showed no significant differences in PSQI or secondary outcomes between the melatonin and placebo groups at either time point. The findings suggest melatonin does not improve sleep quality or associated postoperative outcomes following TKA.
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