Diclofenac, ibuprofen, and celecoxib improve function and pain in knee OA patients .
This report has been verified
by one or more authors of the
original publication.
The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial.
Osteoarthritis Cartilage. 2013 Sep;21(9):1400-8100 patients enrolled in this study to determine the effects of specific nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis of the knee. High and low doses of celecoxib, diclofenac and ibuprofen were administered for 2 weeks prior to TKA operation. The results taken just before the operation suggest that Interleukin-6 (IL-6), tumor necrosis factor-alpha and vascular endothelial growth factor concentrations were decreased with every drug therapy excluding the low dose of ibuprofen which only decreased IL-6. Western Ontario and McMaster University index scores improved with all drugs and dosage levels.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
