Thirty-two patients with chronic lateral epicondylalgia (LE) were randomized to receive an injection with single dose pf high-molecular-weight hyaluronic acid (HA) or 3 doses of dextrose prolotherapy (DPT). The primary outcomes of interest included pain at rest, during movement, and at night on a Visual Analogue Scale (VAS), and physical function evaluated with the Quick-Disabilities of the Arm, Shoulder, and Hand (Q-DASH) score. Secondary outcomes of interest included grip strength. All outcomes were measured at 6 and 12 weeks follow up. Results revealed that whilst both groups reported improvements in pain, function and grip strength, the improvement from baseline at 12 weeks for VAS pain at rest (p=0.04), during movement (p=0.04), and at night (p=0.03) and Q-DASH scores were statistically significantly greater in the DPT group compared to the HA group.