Impact of Dextrose Injection Therapy for Chronic Anterior Talofibular Ligament Sprain: A Randomized Controlled Trial.
OrthoEvidence Journal (OE Journal) - ACE Report
Epub Ahead of Print
Arch Phys Med Rehabil . 2026 Feb;107(2):162-168.Study Summary
27 patients with chronic anterior talofibular ligament sprains (without rupture) were randomized to receive a home-based physiotherapy program combined with either a single 15% dextrose injection or a normal saline injection into the affected ligament. The outcomes of interest include pain, function, ligament thickness, and range of motion. Results revealed, other than a greater pain pressure threshold at 12 weeks in favour of dextrose injection, no differences in all outcomes, at all timepoints up to 12 weeks. These findings indicate that adding dextrose therapy injections to a home-exercise program does not provide any clinical advantage over a placebo injection.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
Are you affiliated with one of our partner associations?
Click here to gain complimentary access as part your association member benefits!
0 of 4 monthly FREE articles unlocked
