Denosumab reduces risk of fractures in post-menopausal women .
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Denosumab for Prevention of Fractures in Postmenopausal Women with Osteoporosis
N Engl J Med. 2009 Aug 20;361(8):756-65. Epub 2009 Aug 11.7868 women with osteoporosis, having a bone mineral density T score of less than -2.5 but no less than -4.0, were randomized to receive either injection with denosumab or an injection with placebo. Denosumab has been proposed to decrease bone resorption and thus improve bone mineral density in those patients with osteoporosis. This study aimed to assess the efficacy of denosumab injection as a treatment for osteoporosis, measured by occurrence of new vertebral fractures. The results from this study indicated that at 3 years the denosumab injections produced a reduction in new vertebral fractures compared to the placebo group.
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