Denosumab increases bone mineral density in male patients with low BMD .
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original publication.
A Randomized, Placebo-Controlled Study of the Effects of Denosumab for the Treatment of Men with Low Bone Mineral Density
J Clin Endocrinol Metab. 2012 Sep;97(9):3161-9. doi: 10.1210/jc.2012-1569. Epub 2012 Jun 21242 male patients with low bone mineral density were randomized to receive treatment with denosumab or a placebo to determine the effect of denosumab on bone mineral density in the male population. After 1 year of treatment, the denosumab group demonstrated a significantly greater increase in bone mineral density than the control group at the lumbar spine, total hip, femoral neck, trochanter, and the one third radius. There was also a significant decrease in serum CTX levels in the denosumab group at 15 days. The two groups did not differ significantly with respect to adverse events.
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