Effectiveness of Denervation Therapy on Pain and Joint Function for Patients with Refractory Knee Osteoarthritis: A Systematic Review and Meta-Analysis

この研究はハイインパクトの可能性があります。 OEのAI駆動型ハイインパクト指標は、論文が掲載されたジャーナルと論文自体の科学的内容の両方からのシグナルを統合することで、論文が持つ可能性の高い影響力を推定します。 最先端の自然言語処理を用いて開発されたOEハイインパクトモデルは、ジャーナルのインパクトファクターのみよりも、研究の将来の引用実績をより正確に予測します。 これにより、臨床的に意義のある研究をより早く認識することが可能になり、読者は将来の診療を形成する可能性が最も高い論文に集中することができます。

6 studies (408 patients) were included in this meta-analysis which investigated the efficacy of denervation therapy compared to control (sham; genicular nerve block; conventional analgesic therapy; intra-articular knee injections) for the relief of pain and improvement of function, up to 24 weeks post-treatment in patients with knee osteoarthritis. The outcomes of interest included pain on a Visual Analog Scale (VAS), the proportion of patients with at least a 50% reduction from baseline in pain score, and the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index. Follow up was performed at 4 weeks, 12 weeks and 24 weeks post-treatment. Pooled results revealed significantly favourable VAS pain scores in the denervation group at all time points. Additionally, the proportion of patients with a minimum 50% reduction in pain score was significantly higher in the denervation group at 12 weeks and 24 weeks. Lastly, pooled WOMAC total score was significantly in favour of the denervation group at 4 weeks and 12 weeks, but was not significantly different between the denervation group and control group at 24 weeks.