Comparison of efficacy and safety of two single injection hyaluronic acid preparations for knee OA .
This study has been identified as potentially high impact.
OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself.
Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone.
This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.
Comparison of Single Intra-Articular Injection of Novel Hyaluronan (HYA-JOINT Plus) with Synvisc-One for Knee Osteoarthritis: A Randomized, Controlled, Double-Blind Trial of Efficacy and Safety
J Bone Joint Surg Am. 2017 Mar 15;99(6):462-471132 patients with mild-to-moderate, symptomatic knee osteoarthritis were randomized to a single injection of either HYA-JOINT Plus (SciVision Biotech) or Synvisc-One (Sanofi-Aventis). Patients were assessed over a 6-month follow-up for patient-reported outcome measures, functional performance measures, patient satisfaction, and rate of adverse events. Pain assessed using a visual analog scale was significantly lower in the HYA-JOINT Plus group compared to the Synvisc-One group at 1, 3, and 6 months, but pain assessed on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) did not significantly differ between groups at any point. WOMAC Stiffness score at 6 months was also significantly lower in the HYA-JOINT Plus group compared to the Synvisc-One group. All other outcomes demonstrated no significant differences between groups over the duration of follow-up.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
