Comparison of combined hyaluronic acid (HA) and corticosteroid vs. HA alone injection for knee OA .
Intra-articular, single-shot co-injection of hyaluronic acid and corticosteroids in knee osteoarthritis: A randomized controlled trial
Exp Ther Med. 2018 Sep;16(3):1928-1934. doi: 10.3892/etm.2018.6371120 patients with Kellgren-Lawrence grade II-IV knee osteoarthritis were randomized to intra-articular injection with either a combination of hyaluronic acid and corticosteroid, or hyaluronic acid alone. Patients were followed-up for 6 months post treatment for outcomes related to pain on a visual analog scale and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Between groups, both VAS pain and WOMAC assessments significantly favoured the HA+CS group compared to the HA alone group at 1 week, 1 month, and 3 months; differences between groups at 6 months were not significant. However, when the change from baseline to 6 months was analyzed within each group, neither outcome measured demonstrated a significant within-group difference.
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