Combined teriparatide and denosumab treatment increased BMD in postmenopausal osteoporosis .
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Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial
Lancet. 2013 Jul 6;382(9886):50-6. doi: 10.1016/S0140-6736(13)60856-9. Epub 2013 May 15One hundred women with osteoporosis were evaluated to compare the efficacy of teriparatide, denosumab, or combined treatment of both drugs on spinal, femoral, and hip bone mineral density (BMD) at 12 months. They were randomized either to daily 20 ug teriparatide daily, 60 mg denosumab every 6 months, or both. At the final follow up, the combination group had increased significantly in posterioranterior lumbar, femoral-neck, and total-hip BMD compared to denosumab and teriparatide treatments alone.
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