Combined & extended alendronate with teriparatide improves BMD in women with osteoporosis .
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Overlapping and continued alendronate or raloxifene administration in patients on teriparatide: effects on areal and volumetric bone mineral density--the CONFORS Study
J Bone Miner Res. 2014 Aug;29(8):1777-85125 postmenopausal women with osteoporosis who had undergone 9 months of teriparatide monotherapy were randomized to three treatment groups. Patients were allocated to either (1) continued 9 months combined teriparatide/alendronate therapy followed by 12 months extended alendronate; (2) continued 9 months combined teriparatide/raloxifene followed by 12 months extended raloxifene, or (3) continued 9 months teriparatide monotherapy followed by 12 months of calcium and vit D supplementation. Results indicated overall the greatest effect for increasing areal and volumetric bone mineral density in the group who received combined teriparatide/alendronate therapy followed by extended alendronate.
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