Combination of Pregabalin and Naproxen Superior to Naproxen in Reducing Pain in Ankle Fracture .
Is perioperative use of a combination of pregabalin and naproxen superior to naproxen only in reducing pain in ankle fractures? A prospective, randomized, multicenter study.
J Orthop Surg Res. 2024 Dec 26;19(1):882.Seventy patients with rotatory ankle fractures were randomized to receive either naproxen alone (n=35) or naproxen plus pregabalin (n=35). The primary outcome was postoperative pain measured by the visual analog scale (VAS). Secondary outcomes included opioid consumption, adverse effects, and functional scores (Olerud and Molander Score, A-FORM) over a six-month follow-up. Overall, the results of the study revealed no significant differences in pain scores, opioid use, or functional outcomes between groups, although dizziness and somnolence were more frequent in the pregabalin group at 48–72 hours. The findings suggest that adding pregabalin to naproxen does not enhance analgesia but may increase side effects.
Unlock the Full ACE Report
You have access to 4 more FREE articles this month.
Click below to unlock and view this ACE Reports
Unlock Now
Critical appraisals of the latest, high-impact randomized controlled trials and systematic reviews in orthopaedics
Access to OrthoEvidence podcast content, including collaborations with the Journal of Bone and Joint Surgery, interviews with internationally recognized surgeons, and roundtable discussions on orthopaedic news and topics
Subscription to The Pulse, a twice-weekly evidence-based newsletter designed to help you make better clinical decisions
Exclusive access to original content articles, including in-house systematic reviews, and articles on health research methods and hot orthopaedic topics
Or upgrade today and gain access to all OrthoEvidencecontent for as little as $1.99 per week.
Already have an account? Log in
0 of 4 monthly FREE articles unlocked
