2021 COA/CORS/CORA Annual Meeting: Effect of Oral Anticoagulant Use on Surgical Delay and Mortality in Hip Fracture: A Systematic Review and Meta-Analysis

Thirty-four studies involving 39,446 patients were included in this systematic review and meta-analysis comparing anticoagulated patients and non-anticoagulated patients. Outcomes of interest included the time to surgery, odds of having surgery beyond the recommended 48 hours from admission, and the odds of 30-day all cause mortality. Pooled comparisons between direct oral anticoagulants and Vitamin K antagonists were also performed. Resulted revealed that anticoagulated patients were delayed 13.7 hours to surgery compared to non-anticoagulated patients. Moreover, the odds of a >48 hour delay in operation and the odds of 30 day all cause mortality were significantly higher in the anticoagulated patient group compared to the non-anticoagulated group. No significant differences in all outcomes were observed between direct oral anti-coagulants and Vitamin K antagonists.